There have been no side effects or complications with medications observed in the studies nor have we received any reports from past customers taking the supplements. However you should still consult your doctor to make sure that the medicine you are taking is not fat soluble. Fat-soluble medications and vitamins (K, A, E and D & essential fatty acids) must be taken two hours before or after taking the supplement so that chitosan’s fat-binding properties don’t inhibit the normal function of those medications or vitamins. Otherwise, those medications and vitamins may be trapped by the supplement just like how it traps fat. Speak with your physician first about the medication you are taking and its interaction with the supplement.